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Structures et fonctions des chaperons moléculaire



Publications de l'équipe



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 Anglès F, Castanié-Cornet MP, Slama N, Dinclaux M, Cirinesi AM, Portais JC, Létisse F Genevaux P. 2017 Multilevel interaction of the DnaK/DnaJ(HSP70/HSP40) stress-responsive chaperone machine with the central metabolism.(PMID:28128357) Sci Rep [2017, 7:41341].
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 Schlegel S, Genevaux P, de Gier. 2016 Isolating Escherichia coli strains for recombinant protein production. Cell Mol Life Sci. Oct 11. Review. PMID: 27730255
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 Bordes P, Sala AJ, Ayala S, Texier P, Slama N, Cirinesi AM, Guillet V Mourey L Genevaux P. 2016 Chaperone addiction of toxin-antitoxin systems. Nat Commun Nov 9;7:13339. PMID: 27827369. Hyperlink
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 Garcie C, Tronnet S, Garénaux A, McCarthy AJ, Brachmann AO, Pénary M, Houle S, Nougayrède JP, Piel J, Taylor PW, Dozois CM, Genevaux P, Oswald E, Martin P. 2016 The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli. J Infect Dis. 2016 Sep 15;214(6):916-24. doi: 10.1093/infdis/jiw294.PMID: 27412582.
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 Ruiz-González MX, Czirják GÁ, Genevaux P, Møller AP, Mousseau TA, Heeb P. 2016 Resistance of Feather-Associated Bacteria to Intermediate Levels of Ionizing Radiation near Chernobyl. Sci Rep. Mar 15;6:22969. doi: 10.1038/srep22969. hyperlink
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 Schlegel S¥, Genevaux P, de Gier J-W. 2015. De-convoluting the Genetic Adaptations of E. coli C41(DE3) in Real Time Reveals How Alleviating Protein Production Stress Improves Yields. Cell Rep. Mar 10. pii: S2211-1247(15)00175-8. doi: 10.1016/j.celrep.2015.02.029.
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Sala A#, Bordes P, Genevaux P. 2014. Multitasking SecB chaperones in bacteria. Front. Microbiol. 5:666. doi: 10.3389/fmicb.2014.00666 (review).
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Götzke H, Palombo I, Muheim C, Perrody E, Genevaux P, Kudva R, Müller M, Daley OD. 2014. YfgM is an Ancillary Subunit of the SecYEG Translocon in Escherichia coli. J. Biol. Chem. 289:19089-19097.
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Castanié-Cornet MP, Bruel N, Genevaux P. 2014. Chaperone networking facilitates protein targeting to the bacterial cytoplasmic membrane. BBA - Molecular Cell Research. 2014 Aug 1843(8):1442-56. Review, Special issue "SI: Protein trafficking & Secretion in Bacteria".
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Sala A, Bordes P, Genevaux P. 2014. Multiple toxin-antitoxin systems in Mycobacterium tuberculosis. Toxins (Basel). 6(3):1002-1020. Review, Special issue on toxin-antitoxins.
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Sala A, Calderon V, Bordes P, Genevaux P. 2013. TAC from Mycobacterium tuberculosis: a paradigm for toxin-antitoxin systems controlled by SecB-like chaperones. Cell Stress and Chaperones. 18:129-135.
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Sala A, Bordes P, Fichant G, Genevaux P. 2012. Toxin-antitoxin systems in Mycobacterium tuberculosis. In Prokaryotic Toxin-Antitoxins, Springer, Kenn Gerdes (Ed.), INSB 978-3642-33252-4.
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Bruel N, Castanié-Cornet MP, Cirinesi AM, Koningstein G, Georgopoulos C, Luirink J, Genevaux P. 2012. Hsp33 controls Elongation Factor-Tu stability and allows Escherichia coli growth in the absence of the major DnaK and Trigger Factor chaperones. J. Biol. Chem. 287: 44435-44446.
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Perrody E, Cirinesi AM, Desplats C, Keppel F, Schwager F, Tranier S, Georgopoulos C, Genevaux P. 2012. A Bacteriophage-Encoded J-Domain Protein Interacts with the DnaK/Hsp70 Chaperone and Stabilizes the Heat-Shock Factor σ32 of Escherichia coli. PLoS Genet. 11 :e1003037. Epub 2012 Nov 1.
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Calloni G, Chen T, Schermann SM, Chang HC, Genevaux P, Agostini F, Tartaglia GG, Hayer-Hartl M, Hartl FU. 2012. DnaK Functions as a Central Hub in the Escherichia coli Chaperone Network. Cell Reports 1:251-264.
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Champ S, Puvirajesinghe TM, Perrody E, Menouni R, Genevaux P, Ansaldi M. 2011. Chaperone-assisted excisive recombinantion, a solitary role for DnaJ (Hsp40) chaperone in lysogeny escape. J. Biol. Chem. 286:38876-38885.
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Maillard J, Genevaux P, Holliger C. 2011. Redundancy and specificity of multiple trigger factor chaperones in Desulfitobacteria. Microbiology. 157:2410-21.
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Bordes P, Cirinesi AM, Ummels R, Sala A, Sakr S, Bitter W, Genevaux P. 2011. SecB-like chaperone controls a toxin-antitoxin stress-responsive system in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA. 108:8438-8443.
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Maddalo G, Stenberg-Bruzell F, Götzke H, Toddo S, Björkholm P, Eriksson H, Chovanec P, Genevaux P, Lehtiö J, Ilag LL, Daley DO. 2011. Systematic Analysis of Native Membrane Protein Complexes in Escherichia coli. J. Proteome Res. 10:1848-1859.
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Jong WS, Ten Hagen-Jongman CM, Ruijter E, Orru RV, Genevaux P, Luirink J. YidC is involved in the biogenesis of the secreted autotransporter Hbp. J Biol Chem. 2010 Oct 19. [Epub ahead of print]
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Sakr S, Cirinesi AM, Ullers RS, Schwager F, Georgopoulos C, Genevaux P.Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones. J Biol Chem. 2010 Jul 23;285(30):23506-14. Epub 2010 May 26.
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Horne BE, Li T, Genevaux P, Georgopoulos C, Landry SJ.The Hsp40 J-domain stimulates Hsp70 when tethered by the client to the ATPase domain. J Biol Chem. 2010 Jul 9;285(28):21679-88. Epub 2010 May 6.
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Wagner S, Pop O, Haan GJ, Baars L, Koningstein G, Klepsch MM, Genevaux P, Luirink J, de Gier JW. 2008. Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC. J. Biol. Chem. 283:17881-17890.
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Genevaux P, Georgopoulos^ C and Kelley WL. 2007. The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions. Mol. Microbiol. Oct 5; [Epub ahead of print].
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Ullers R, Genevaux P and Luirink J. 2007. Cotranslational protein targeting in Escherichia coli. The Enzymes, Vol. XXV: Molecular machines involved in protein transport across cellular membranes. Academic Press, Ed. Dalbey RE, Koehler CM and Tamanoi F: p3-34.
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Ullers RS, Ang D, Schwager F, Georgopoulos C and Genevaux P. 2007. Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coliProc. Natl. Acad. Sci. USA. 104:3101-3106.
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Lakshmipathy SK, Tomic S, Kaiser CM, Chang HC, Genevaux P, Georgopoulos C, Barral JM, Johnson AE, Hartl FU and Etchells SA. 2007. Identification of nascent chain interaction sites on Trigger Factor. J. Biol. Chem. 282:12186-12193.
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Tu Quoc PH, Genevaux P, Pajunen M, Savilahti H, Georgopoulos C, Schrenzel J and Kelley WL. 2007. Isolation and characterization of biofilm formation-defective mutants of Staphylococcus aureus. Infect. Immun. 75:1079-1088.
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Cogelja Cajo G, Horne BE, Kelley WL, Schwager F, Georgopoulos C and Genevaux P. 2006. The role of the DIF motif of the DnaJ (Hsp40) co-chaperone in the regulation of the DnaK (Hsp70) chaperone cycle. J. Biol. Chem. 281:12436-12444.
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Maranic P, Wagnera S, Baars L, Genevaux P, de Gier J-W, Nilsson I-G, Casadioc R and von Heijne G. 2006. New Escherichia coli outer membrane proteins identified through prediction and experimental verification. Protein Sci. 14:884-889.
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Jong WSP, ten Hagen-Jongeman CM, Genevaux P, Brunner J, Oudega B and Luirink J. 2004. Trigger Factor interacts with the signal peptide of the nascent Tat substrates but does not play a critical role in Tat-mediated export. Euro. J. Biochem. 271:4779-4787.
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Gur E, Brian D, Genevaux P, Georgopoulos C and Ron EZ. 2004. The Escherichia coli DjlA and CbpA proteins can substitute for DnaJ in DnaK-mediated protein disaggregation. J. Bacteriol. 186:7236-7242.
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Ullers R, Luirink J, Harms N, Schwager F, Georgopoulos C and Genevaux P. 2004. SecB is a bona fide generalized chaperone in Escherichia coli. Proc. Natl. Acad. Sci. USA. 101:7583-7588.
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Agashe VR, Guha S, Chang H-C, Genevaux P, Hayer-Hartl M, Stemp M, Georgopoulos C,. Hartl FU and Barral JM. 2004. Function of Trigger Factor and DnaK in multidomain protein folding: Increase in yield at the expense of folding speed. Cell. 117:199-209.
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Genevaux P, Keppel F, Schwager F, Langendijk-Genevaux PS, Hartl FU and Georgopoulos C. 2004. In vivo dissection of Trigger Factor and DnaK overlapping functions.EMBO Rep. 5:195-200.
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Genevaux P, Lang F, Schwager F, Vatikar JV, Rundell K, Pipas JM. Georgopoulos C and Kelley WL. 2003. Simian Virus 40 (SV40) T antigens and J-domains: analysis of Hsp40 co-chaperone functions in Escherichia coli. J. Virol. 77:10706-10713.
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Genevaux P, Schwager F, Georgopoulos C and Kelley WL. 2002. Amino acid residues essential for the in vivo activity of the Escherichia coli DnaJ (Hsp40) J-domain by scanning mutagenesis.Genetics 162:1045-1053.
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Kluck CJ, Patzelt H, Genevaux P, Brehmer D, Bukau B and Mayer MP. 2002. Characterization of HscC, a specialized Hsp70 chaperone of Escherichia coli. J. Biol. Chem. 227:41060-41069.
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Genevaux P, Schwager F, Georgopoulos C and Kelley WL. 2001. The djlA gene acts synergistically with dnaJ in promoting Escherichia coli growth. J. Bacteriol. 183:5747-5750.
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Genevaux P, Wawrzynow A, Zylicz M, Georgopoulos C and Kelley WL. 2001. DjlA is a third DnaK co-chaperone of Escherichia coli and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction. J. Biol. Chem. 276:7906-7912.





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