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Le Laboratoire de Microbiologie et Génétique Moléculaires

UMR 5100

 

 

The Laboratoire de Microbiologie et Génétique Moléculaires (LMGM) studies the organization, evolution and expression of the genomes of bacteria and bacteriophage. Our research ranges from the study of single molecules to living bacterial cells and their interaction with the environment. This research is based on approaches that include molecular genetics, biochemistry, genomics and bioinformatics. The bacteria and bacteriophage that we study are model organisms interesting for fundamental research as well as for applications in biotechnology, the food industry and the medical sciences.

 
 

Le Laboratoire de Microbiologie et Génétique Moléculaires supports "Sciences en marche"
Sciences en marche

News Archives


 

 

 

 

 

  •   Chaperone addiction of toxin-antitoxin systems

    Bacterial toxin-antitoxin (poison-antidote) systems, in which a labile antitoxin binds and inhibits a noxious toxin, can promote adaptation, persistence and multi-drug tolerance by modulating bacterial growth in response to stress. Some atypical toxin-antitoxins, known as tripartite toxin-antitoxin-chaperone (TAC) modules, also include a stress-responsive molecular chaperone that facilitates folding and protects the antitoxin from degradation. Using a TAC module from the major human pathogen Mycobacterium tuberculosis as a model to investigate the molecular mechanisms by which classical TAs can become ‘chaperone-addicted’, researchers form the “Laboratoire de microbiologie et génétique moléculaires, Centre de biologie integrative” and from the “Institut de pharmacologie et de biologie structural” in Toulouse have now identified a short chaperone addiction sequence (ChAD) within TAC antitoxins, to which the chaperone binds and which can be transferred to other proteins to make them chaperone-dependent. This mechanism might be used to optimize the expression and folding of heterologous proteins in bacterial hosts for biotechnological or medical purposes. This work is published in Nature Communications 7, 2016.

    Pubmed

    plusPour en savoir plus

  •   Reception of students for the festival of science

    On October 14th, CBI hosted an open day with high-school students. The LBME and the LMGM accommodated scientific senior secondary school students for an original discovery of the world of research. The students could visit the laboratories, discuss with researchers during mini-conferences and take part in many interactive workshops animated by researchers, engineers, technicians, and PhD students of the two laboratories.
    Beautiful human and scientific experiences and experiments.

  •   PhD defense : Léa Marie (Polard Team)

    Functional study of the homologous recombination pathway effectors acting during genetic transformation of Streptococcus pneumoniae pathogen.
    October 21 2016 - 14h00 - IBCG Conference room.

  •   PhD defense : Franck Pasta (Bouet Team)

    From DNA repair in pneumococcus to genome partitioning in the Burkholderiales.
    October 19 2016 - 10h00 - Einstein Amphitheatre, UPS.

  •   PhD defense : Alix Corneloup (Ton-Hoang Team)

    The spread of REP sequences in bacterial genomes, characterising the activities of the TnpAREP proteins.
    October 18 2016 - 14h00 - IBCG Conference room.

  •   PhD defense : Florian Fournes (Cornet Team)

    Study of the Xer system through the horizontal and vertical genetic transmission in bacteria.
    October 03 2016 - 14h00 - IBCG Conference room.

  •   PhD defense : Elise Lebailly (Cornet Team)

    The role of the E. coli. chromosome terminus in positioning, chromosomal segregation, and division control.
    September 30 2016 - 14h00 - IBCG Conference room.

  •   Destabilization of the genome of the bacterium Burkholderia cenocepacia

    Burkholderia cenocepacia, a bacterial pathogen to which sufferers from cystic fibrosis are highly susceptible, has three chromosomes. Dave Lane and Franck Pasta at the LMGM have shown by fluorescence microscopy that transmission of chromosome copies to daughter cells is sequential - the largest first, the smallest last. Each chromosome codes for a mitotic system whose inactivation disrupts the transmission and causes cellular anomalies. This work, published in PLoS Genetics, raises the prospect of targeting these mitotic systems for anti-B.cencepacia treatment.

    Pubmed

    plusPour en savoir plus

 

New members :

 

Peter REDDER, Professeur, UPS dans l'quipe REDDER

Manuel CAMPOS, Post-Doctorant dans l'quipe CORNET

Calum JOHNSTON, Chargé de Recherche, CNRS dans l'quipe POLARD

Raffaele IEVA, Chargé de Recherche, CNRS dans l'quipe IEVA

David DE LEMOS, Doctorant dans l'quipe POLARD

Emeline VERNHES, Post-Doctorant dans l'quipe POLARD

Ignacio GONZALEZ, Chargé de Recherche, CNRS dans l'quipe CARPOUSIS

Cecile ALBENNE, Maître de Conférences, UPS dans l'quipe IEVA

Camille PEYRE, Stagiaire dans l'quipe CORNET

Céline PÉLISSIER, Adjoint technique, UPS dans l'quipe REDDER

David RANAVA, Post-Doctorant dans l'quipe IEVA

Gladys MUNOZ, Technicien, CNRS dans l'quipe REDDER

 

MLST
: This site hosts the two MultiLocus Sequence Typing (MLST) schemes developed for Lactococcus lactis.
 



ISFinder: This database provides a list of insertion sequences isolated from eubacteria and archae .

 


ABCdb : a data base on the ABC transporters

 

 

T4-type Phage Genome Website

 

 

 


 

Seminars Toulouse Microbiology

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Laboratoire de Microbiologie
et Génétique Moléculaires
UMR 5100