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Le Laboratoire de Microbiologie et Génétique Moléculaires

UMR 5100

 

 

The Laboratoire de Microbiologie et Génétique Moléculaires (LMGM) studies the organization, evolution and expression of the genomes of bacteria and bacteriophage. Our research ranges from the study of single molecules to living bacterial cells and their interaction with the environment. This research is based on approaches that include molecular genetics, biochemistry, genomics and bioinformatics. The bacteria and bacteriophage that we study are model organisms interesting for fundamental research as well as for applications in biotechnology, the food industry and the medical sciences.

 
 

Le Laboratoire de Microbiologie et Génétique Moléculaires supports "Sciences en marche"
Sciences en marche

News Archives


 

 

 

 

 

  •   A new light on DNA segregation in bacteria

    The molecular machine that segregates DNA in bacteria relies on the assembly of several hundreds of ParB proteins. Along with the imaging and capture of the in vivo complexes coupled with high-throughput DNA sequencing and physico-mathematical modeling of these data, the researchers have discriminated between the different proposed models. They have demonstrated that a robust mechanism relying on the stochastic assembly of a large nucleoprotein complex drives the partition process. This collaborative work between molecular biologists and theoretical physicists explains how all ParB groups together around only a few specific sites. This study has been published in the journal Molecular System Biology.
    A conserved mechanism drives partition complex assembly on bacterial chromosomes and plasmids. Debaugny, R.E., Sanchez, A., Rech, J., Labourdette, D., Dorignac, J., Geniet, F., Palmeri, J., Parmeggiani, A., Boudscoq, F., Anton Leberre, V., Walter, J.-C. and Bouet, J.-Y.
    Molecular Systems Biology (2018) 14, e8516 Published online 16.11.2018

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  •   A pause is required to transform

    The bacterium Streptococcus pneumoniae, commonly known as the pneumococcus, is able to integrate exogenous DNA into its genome during natural genetic transformation. This process requires the development of a transient physiological state named competence. Researchers from the LMGM (Nature Communications – 2017-11-20) have shown that a cell division arrest is programmed in competent pneumococcal cells to ensure that transformation is complete before resumption of cell division. This arrest provides this pathogen with the maximum potential for genetic diversity and adaptation.

    Pubmed

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New members :

 

Peter REDDER, Professeur, UPS dans l'équipe REDDER

Manuel CAMPOS, Post-Doctorant dans l'équipe CORNET

Calum JOHNSTON, Chargé de Recherche, CNRS dans l'équipe POLARD

Raffaele IEVA, Chargé de Recherche, CNRS dans l'équipe IEVA

David DE LEMOS, Doctorant dans l'équipe POLARD

Emeline VERNHES, Post-Doctorant dans l'équipe POLARD

Ignacio GONZALEZ, Chargé de Recherche, CNRS dans l'équipe CARPOUSIS

Cecile ALBENNE, Maître de Conférences, UPS dans l'équipe IEVA

Camille PEYRE, Stagiaire dans l'équipe CORNET

Céline PÉLISSIER, Adjoint technique, UPS dans l'équipe REDDER

Gladys MUNOZ, Technicien, CNRS dans l'équipe REDDER

DONNA-JOE BIGOT, Assistant Ingénieur, CNRS dans l'équipe GENEVAUX

 

MLST
: This site hosts the two MultiLocus Sequence Typing (MLST) schemes developed for Lactococcus lactis.
 



ISFinder: This database provides a list of insertion sequences isolated from eubacteria and archae .

 


ABCdb : a data base on the ABC transporters

 

 

T4-type Phage Genome Website

 

 

 


 

Seminars Toulouse Microbiology

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Laboratoire de Microbiologie
et Génétique Moléculaires
UMR 5100